Respiratory Muscle Paralysis Associated With Colistin, Polymyxin B, and Muscle Relaxants Drugs

Respiratory Muscle Paralysis Associated With Colistin, Polymyxin B, and Muscle Relaxants Drugs

Polymyxins B and E (colistin) exert a bactericidal effect on the gram-negative bacterial cell wall, causing permeability changes in the cytoplasmic membrane, leading to cell death. Their use was substantially decreased in clinical practice from the 1970s to 2000s due to their significant nephrotoxicity and neurotoxicity compared to the newly introduced antibiotics. The increasing prevalence of ...

Polymyxin B and heart muscle.

The effects of the polypeptide antibiotic, polymyxin B, on myocardial contractility were studied in t;e isolated rat heart muscle. Five different doses of polymyxin B were tested. There were no changes in contractility with does ranging from the clinical therapeutic value to three times greater. There was an initial increase and then depression with a dose six times greater than the therapeutic...

Use of muscle relaxants.

Muscle relaxants and antispasticity agents.

Muscle relaxants make up a heterogeneous group of agents and can have a clinically significant role in the treatment of chronic muscle pain. These medications are not without possible serious side effects; hence, care should be taken in deciding on their appropriateness and ongoing monitoring performed, if prescribed.

Muscle relaxants and Bier's block.

Sir We are grateful for the opportunity to reply to your correspondent. If no less an authority than Professor J. M. Hunter can write a sentence beginning 'With the advent of the two new non-depolarizing muscle relaxants, atracurium and vecurionium . . .' (Hunter, 1987), we feel we may use the same expression. Ethical committee approval for the addition of atracurium to Bier's blocks was obtain...